Those who have rejected God's truth and turned to wickedness are considered to have a reprobate mind, as described in Romans 1:28. This state of being is characterized by a deliberate rejection of God's will, leading to a downward spiral of immorality and idolatry, as seen in Romans 1:24-28. The apostle Paul also warns of reprobate individuals in 2 Timothy 3:8, who oppose the truth and are corrupt in their motives. However, it is worth noting that 1 Timothy 2:4 and James 2:19 suggest that God desires all people to come to repentance and acknowledge the truth, offering hope for redemption from a reprobate state.
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Furthermore, since they did not see fit to acknowledge God, He gave them up to a depraved mind, to do what ought not to be done.
Just as Jannes and Jambres opposed Moses, so also these men oppose the truth. They are depraved in mind and disqualified from the faith.
Therefore God gave them over in the desires of their hearts to impurity for the dishonoring of their bodies with one another. They exchanged the truth of God for a lie, and worshiped and served the creature rather than the Creator, who is forever worthy of praise! Amen. For this reason God gave them over to dishonorable passions. Even their women exchanged natural relations for unnatural ones. Likewise, the men abandoned natural relations with women and burned with lust for one another. Men committed indecent acts with other men, and received in themselves the due penalty for their error. Furthermore, since they did not see fit to acknowledge God, He gave them up to a depraved mind, to do what ought not to be done.
and, “A stone of stumbling and a rock of offense.” They stumble because they disobey the word—and to this they were appointed.
The woman was dressed in purple and scarlet, and adorned with gold and precious stones and pearls. She held in her hand a golden cup full of abominations and the impurities of her sexual immorality.
They profess to know God, but by their actions they deny Him. They are detestable, disobedient, and unfit for any good deed.