What does it mean if you say someone is reprobate?

[b]reprobate[/b] (online dictionary)

[i]–noun[/i]

1.\ta depraved, unprincipled, or wicked person: a drunken reprobate.
2.\ta person rejected by God and beyond hope of salvation.

[i]–adjective[/i]

3.\tmorally depraved; unprincipled; bad.
4.\trejected by God and beyond hope of salvation.

[i]–verb (used with object)[/i]

5.\tto disapprove, condemn, or censure.
6.\t(of God) to reject (a person), as for sin; exclude from the number of the elect or from salvation.

[b]apostate[/b] (online dictionary)

[i]-noun[/i]

1.\ta person who forsakes his religion, cause, party, etc.

[i]–adjective[/i]

2.\tof or characterized by apostasy.