Do you not know (50) (agnoeo from a = not + noéo = perceive, understand) not have information about, to not know, to not understand (Mk 9:32, Lk 9:45), to be unaware of, to not recognize (Ac 13:27), to be ignorant of (to lack information concerning something). Agnoeo conveys the nuance of lacking the ability to understand in He 5:2 and of inexcusable moral/ethical ignorance (even disregard) in Ro 10:3). Know (ginosko) which is the converse of agnoeo is a key word in Romans (Ro 1:21-note; Ro 2:18-note; Ro 3:17-note; Ro 6:6-note; Ro 7:1-note, Ro 7:7-note, Ro 7:15-note; Ro 10:19-note; Ro 11:34-note) and "not knowing" is also a key in this great epistle, where Paul uses agnoeo to introduce a spiritual truth his readers should be aware of (Ro 2:4, 6:3, 7:1, 10:3, 11:25, cp 1Co 10:1, 12:1, 2Co 2:11, 1Th 4:13-note). Someone has quipped that when Paul begins a sentence with "do you not know" (or "are ye ignorant") concerning the saints, it often turns out that they are ignorant! Agnoeo: 22x/21 verses in NAS rendered: have no knowledge(1), ignorance(1), ignorant(2), ignorantly(1), not know(2), not knowing(2), not recognize(1), not recognized(1), not understand(2), recognizing not(1), unaware(4), uninformed(2),unknown(2). Mark 9:32 But they did not understand this statement, and they were afraid to ask Him. Luke 9:45 But they did not understand this statement, and it was concealed from them so that they might not perceive it; and they were afraid to ask Him about this statement. Acts 13:27 "For those who live in Jerusalem, and their rulers, recognizing neither Him nor the utterances of the prophets which are read every Sabbath, fulfilled these by condemning Him. Acts 17:23 "For while I was passing through and examining the objects of your worship, I also found an altar with this inscription, 'TO AN UNKNOWN (agnostos) GOD.' What therefore you worship in ignorance (not knowing Ac 17:23YTL, this I proclaim to you. Romans 1:13-note And I do not want you to be unaware, brethren, that often I have planned to come to you (and have been prevented thus far) in order that I might obtain some fruit among you also, even as among the rest of the Gentiles. Romans 2:4-note Or do you think lightly of the riches of His kindness and forbearance and patience, not knowing that the kindness of God leads you to repentance? Romans 6:3-note Or do you not know that all of us who have been baptized into Christ Jesus have been baptized into His death? Romans 7:1-note Or do you not know, brethren (for I am speaking to those who know the law), that the law has jurisdiction over a person as long as he lives? Romans 10:3-note For not knowing about God's righteousness, and seeking to establish their own, they did not subject themselves to the righteousness of God. Romans 11:25-note For I do not want you, brethren, to be uninformed of this mystery, lest you be wise in your own estimation, that a partial hardening has happened to Israel until the fulness of the Gentiles has come in; 1Corinthians 10:1 For I do not want you to be unaware, brethren, that our fathers were all under the cloud, and all passed through the sea; 1Corinthians 12:1 Now concerning spiritual gifts, brethren, I do not want you to be unaware. 1Corinthians 14:38 But if anyone does not recognize this, he is not recognized. 2Corinthians 1:8 For we do not want you to be unaware, brethren, of our affliction which came to us in Asia, that we were burdened excessively, beyond our strength, so that we despaired even of life; 2Corinthians 2:11 in order that no advantage be taken of us by Satan; for we are not ignorant of his schemes. 2 Corinthians 6:9 as unknown yet well-known, as dying yet behold, we live; as punished yet not put to death, Galatians 1:22 And I was still unknown by sight to the churches of Judea which were in Christ; 1Thessalonians 4:13-note But we do not want you to be uninformed, brethren, about those who are asleep, that you may not grieve, as do the rest who have no hope. 1Timothy 1:13 even though I was formerly a blasphemer and a persecutor and a violent aggressor. And yet I was shown mercy, because I acted ignorantly in unbelief; Hebrews 5:2-note he can deal gently with the ignorant and misguided, since he himself also is beset with weakness; 2 Peter 2:12-note But these, like unreasoning animals, born as creatures of instinct to be captured and killed, reviling where they have no knowledge, will in the destruction of those creatures also be destroyed, Agnoeo is used 21x in the non-apocryphal Septuagint (LXX) - Gen. 20:4; Lev. 4:13; 5:18; Num. 12:11; 1 Sam. 14:24; 26:21; 2Chr. 16:9; Dan. 9:15; Hos. 4:15 William Newell observes in Romans 7... "we have a chapter of two sections, (1) Ro 7:1-6 and (2) Ro 7:7-25: both of which we are prone to misunderstand and misapply, unless we exercise much prayerful care...The King James, by its failure to translate the chapter's opening word "Or, " to which God gives the emphatic position in this argument, obscures the whole meaning of the passage and context. Unless we connect Romans 7.1 with Romans 6.14, (as the proper translation "or" does), we cannot properly understand the passage." (Romans 7) FOR I AM SPEAKING TO THOSE WHO KNOW THE LAW: ginoskousin (PAPMPD) gar nomon lalo (1SPAI): (Those who know the law: Ro 2:17,18; Ezra 7:25; Pr 6:23; 1Cor 9:8; Gal 4:21) (Ro 7:6; 6:14) For (gar) introduces an explanation. Whenever you encounter a term of explanation, always consider performing the 4P's (pause to ponder and practice the passage) stop, which is facilitated by interrogating the text with the 5W/H'S, asking questions like "What is being explained?". As you perform the 4P's, you will find that you are in essence engaging in the discipline of Biblical Meditation which God promises to richly reward (See Ps 1:2-note, Ps 1:3-note, Joshua 1:8-note). 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